Shabazz, 56, was found unconscious by her daughter at her home in Brooklyn, according to the NYPD.
Police said the death appears to be due to natural causes at this time.
Bernice King, a daughter of the late Martin Luther King Jr., offered her condolences.
Shabazz is the youngest of Malcolm X’s six daughters.
CNN has reached out to the medical examiner’s office and to the Shabazz family.
Last Thursday, two men convicted of the 1965 assassination of Malcolm X were exonerated during a court hearing.
New York County Supreme Court Administrative Judge Ellen Biben granted the motion to vacate the convictions of Muhammad A. Aziz and the late Khalil Islam.